January 19, 2017

The Spring 2017 Biology Seminar Series commences with David W. Scott's talk, "Driving CARs to BARs: The road to engineered human antigen-specific regulatory and cytotoxic T cells."

The specificity of the immune system is powerful and has been harnessed in a novel therapy for cancer, called CARs (for Chimeric Antigen Receptors).  Our lab has applied this approach to create regulatory police CARs that stop harmful immune responses in autoimmunity and hemophilia, and we have now driven them to BARs.

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November 22, 2016

The Fall 2016 Biology Seminar Series concludes with Dr. Jamie Voyles’ talk: How does it end? Shifts in the infectious disease chytridiomycosis and the fate of frogs.

The emergence of infectious disease rarely ends in the complete extinction of host species. Frequently, the level of virulence in a severe disease system shifts such that hosts and pathogens can persist in a shared environment. However, the mechanistic underpinnings of these transitions are not well understood. The lethal fungal disease known as amphibian chytridiomyocosis provides a compelling system to investigate such shifts in infectious disease dynamics. The pathogen that causes chytridiomycosis, Batrachochytrium dendrobatids (commonly called "Bd"), is renown for its ability spread rapidly into amphibian communities and cause extremely high levels of mortality in many different host species. However, some host species have survived initial...

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October 24, 2016

The Fall 2016 Biology Seminar Series continues with Sharon Stranford’s talk: The MAIDS model system: IL-10 and the role of immunosuppression in susceptibility to immunodeficiency

Sharon Stranford studies factors that influence the development of acquired immune deficiency. She and the undergraduate students who work in her research lab employ a mouse model of AIDS (MAIDS) in which some strains of mice develop immune deficiency following exposure to Murine Leukemia Virus (MuLV). This allows them to compare the early immune response patterns of MAIDS-susceptible and MAIDS-resistant mice for clues to immune pathways that bias towards resolution versus immunodeficiency. This is done using a combination of techniques, including comparative gene expression, flow cytometric analysis, enzyme-linked immunosorbant assays (ELISAs) and fluorescence microscopy. 



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October 3, 2016

The Fall 2016 Biology Seminar Series continues with Francie Mercer's talk: Immune subversion by the sexually transmitted parasite Trichomonas vaginalis

Trichomonas vaginalis is a protozoan parasite that causes the most common non-viral STI in the U.S. and worldwide. While complications due to Trichomonas infection can contribute to adverse reproductive outcomes and health disparities, not much is known about how the immune system responds to Trichomonas, or why the infection persists.  We show that human neutrophils are able to kill Trichomonas in a contact- dependent manner that involves antibody opsonization, and that some clinical isolates are resistant to neutrophils.  These “virulent” strains of Trichomonas can also kill other cells of the immune system.
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September 23, 2016

The Fall 2016 Biology Seminar Series continues with Michael A. Anderson's talk: Microbial water quality, drinking water treatment and public health.

September 14, 2016

The Fall 2016 Biology Seminar Series commences with Ralph Appy's talk: What Parasites Can Tell Us About Our Environment: Studies of Fish and Macroinvertebrate Parasites in Urban Southern California Marine Habitats

May 13, 2016

Several Oxy Biology students and faculty attended the Southern California Academy of Sciences (SCAS) conference on Friday, May 6, 2016.



Hannah Munkacsi's poster won for Best Student Poster Presentation of the Southern California Society of Parasitologists (SCSP) 2016 
Best Poster Presentation
Name – Hannah Munkasci
Paper No. – 75
Congratulations Hannah!


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April 14, 2016

Heidi Aronson and Emily Applewhite will present their Biology Honors projects on Tuesday, April 19th.

Heidi Aronson
The specific and exclusive microbiome of the deep-sea bone-eating snail, Rubyspira osteovora
Emily Applewhite
Living in the Hybrid Zone: Testing the Species Squabble with two Mexican Highland Birds
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April 7, 2016

The Spring 2016 Biology Seminar Series concludes with Dr. Kwasi M. Connor's talk: Omic Approaches to Understanding Life in a Fluctuating Environment.

April 1, 2016

The Spring 2016 Biology Seminar Series continues with Dr. Erin Brinton's talk: Drowning corn: Molecular responses of Zea mays ssp. mays to flooding

Flooding is the second leading cause of corn (Zea mays ssp. mays) crop loss in the United States and is further exacerbated by global climate change. While plants require water for growth, too much can impart multiple stresses, one of the greatest of which is limited oxygen availability due to decreased gas diffusion. This limits aerobic respiration, which when coupled with reduced photosynthesis, promotes unchecked carbohydrate consumption to offset inefficient ATP production. Some of the earliest studies of plant low-oxygen responses were undertaken in corn and included observations of changes occurring at multiple levels of gene regulation, from gene transcription through mRNA translation. However, very little has been reported at the genome scale of the responses of corn to...
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